Driving the Biome With Supercomputers: GNS REFSTM (Reverse-Engineering and Forward Simulation) Technology

 
 
 
Drug Discovery Needs
 
Pathway
Databases
 
Small
Physiology
Literature
Fragment
Assembly
 
Data-Driven
GNS
Information on unknown compound MOA
No
No
No
Yes
Discover unknown biology
No
No
No
Yes
Role of customer data in creating models
Tertiary
Secondary
Secondary
Primary
Compound is used in building models
No
N/A
N/A
Yes
Physiological endpoint is used in building models
No
No
N/A
Yes
A priori assumptions about biological system
Yes
Yes
Yes
No
 
Model Design Enables Quantitative Hypothesis
 
In Silico Genetics - knockouts, up regulation
No
No
No
Yes
In Silico Pharmacology - drug combinations
No
Yes
No
Yes
In Silico Dose Response
N/A
Yes
No
Yes
Compound is used in building models
No
N/A
N/A
Yes
Physiological endpoint is used in building models
No
No
N/A
Yes
A priori assumptions about biological system
Yes
Yes
Yes
No
Cost of Obtaining Data
for Modeling/Simulation
N/A
High
High
Moderate