Government-Sponsored Research
National Cancer Institute
Colon Cancer Networks: Linking Modeling to Experiment
The major goal of this project was to develop computational models of signal transduction pathways implicated in colon cancer. These models gave insight into the pathways' dynamic behavior and elucidated their roles in activating known oncogenic target genes.
Amount: $100,000
New York State Office of Science, Technology, and Academic Research
Data-driven Molecularly Detailed Simulation of Escherichia coli
The major goal of this project was to map and model bacterial metabolic pathways.
Amount: $29,048
National Institute of Standards and Technology
Cost-Effective Detection of Efficacious and Non-Toxic Drug Targets via Breakthrough in silico Methods
The major goal of this project is to develop and validate the software that creates dynamic, predictive simulations of normal and cancerous cells with up to 10,000 cellular components as a means of rapidly identifying targets for new, non-toxic drugs.
Amount: $2,000,000
US Department of Energy
Computational Hypothesis Testing: Integrating Heterogeneous Data and Large-Scale Simulation to Generate Pathway Hypotheses
The major goal of this project was to create a computational hypothesis testing framework that combines large-scale dynamic simulation, a database of bioinformatics-derived probable interactions, and numerical parallel architecture data-fitting routines. This platform would be used to explore many "what if?" hypotheses about the functions of genes and proteins within pathways and their downstream effects on molecular concentration profiles and corresponding phenotypes.
Amount: $2,517,930
MITACS: Canadian Network of Centres of Excellence
Mathematics of Information Technology and Complex Systems Award
G-proteins and decision making in single cells
The purpose of this project is to use experimental and computational methods to study G-protein-coupled receptor signaling in single cells. The project will focus on determining how the Gq network integrates input from the angiotensin II and alpha-adrenergic receptors.
Amount: $40,000 CAD
National Heart, Lung, and Blood Institute
Software for Simulating Cardiac Electrical Activity
The major goal of this project is to develop a software platform for exploring models that characterize electrical activity in single heart cells.
Amount: $100,000
Computer Model of Cardiac Signaling Networks
The goal of this project is to model a cardiac signaling network supported by state of the art software facilitating simulation of large-scale, data-driven models of cardiac signaling pathways.
Amount: $100,000
Data Collection and Integration in Cardiac Risk Assessment
The goal of this project is to develop experimental protocols for characterizing ion current/drug interactions and to develop a database for storing and integrating these data into computer simulations.
Amount: $137,800
Simulation Software for Cardiac Arrhythmia Risk Assessment
The goal of this project is to develop a software platform for simulating models of cardiac ion currents, action potentials, and tissue, and to validate the platform using experimental data.
Amount: $1,658,273
Computer Model of the Canine Ventricle
The major goal of this project is to develop a data-driven computer model of the electrical behavior of the canine ventricle.
Amount: $1,931,867
National Science Foundation
Computational Modeling of Cardiac Electrical Response
The goal of this project was to implement and refine a model of a single heart cell, to couple models of single cells in order to model heart tissue, and to use these models to study the mechanisms underlying ventricular fibrillation.
Amount: $100,000